Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease: First Cases Reported In The Brazilian Amazon

Creutzfeldt-Jakob Disease: First Cases Reported In The Brazilian Amazon

Resumen

Objective: report three cases of Creutzfeldt-Jakob disease in the Amazon’s interior, demonstrate the evolution of the clinical picture and diagnosis of the disease, study the relationship between COVID-19 and the triggering or acceleration of the prion disease and analyze the difficulties for diagnosis. Methods: a series of cases composed of three patients with a condition compatible with Creutzfeldt-Jakob disease, where two of them were infected by the coronavirus. It is an observational and descriptive study and the data were collected from the medical records. Results: all three patients had an expected clinical picture for the condition, characterized by myoclonus and neurological decline in several functions, especially cognitive, behavioral, and cerebellar. Two of them had COVID-19, but it is unsure whether there is a relation between it and the triggering or an accelerated progression of the prion disease. In this study, all patients died from sepsis secondary to pneumonia within an interval of 3 to 9 months. Conclusion: The dissemination of knowledge about Creutzfeldt-Jakob disease and professional capacity may be relevant for a more assertive diagnosis in remote places such as the Amazon and its relationship with COVID-19 needs to be better elucidated.

Biografía del autor/a

Francisco Ribeiro Picanço Junior, State University of Pará

MD, State University of Pará (UEPA)

Edrian Werner Carvalho, State University of Pará

MD, State University of Pará (UEPA). 

Francisco Benjamin Sousa Alves, State University of Pará (UEPA)

Faculty of Medicine, State University of Pará (UEPA)

Marcos Manoel Honorato, State University of Pará (UEPA)

MD, PhD, Neurology and Neurosciences, Federal University of São Paulo (UNIFESP).

Randerson José de Araujo Sousa Sousa, State University of Pará (UEPA)

Postgraduate Program in Clinical Medicine, Federal University of Rio de Janeiro (UFRJ). Faculty of Medicine, State University of Pará (UEPA)

Fernando Morgadinho Coelho, Federal University of São Paulo (UNIFESP)

MD, PhD, Department of Neurology and Neurosurgery and Department of Psychobiology, Federal University of São Paulo (UNIFESP).

Publicado
2024-03-05